Fenofibrate Therapy in Carnitine Palmitoyl Transferase Type 2 Deficiency. (3rd December 2012)

• Record Type: Journal Article
• Authors: Hamilton-Craig, I.; Yudi, M.; Johnson, L.; Jayasinghe, R.
• Other Names: Wanner Christoph Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2012(2012)
• Publication Date: 2012-12-03
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2012/163173
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : Bezafibrate therapy has been shown to improve beta-oxidation of fatty acids and to reduce episodes of rhabdomyolysis in patients with carnitine palmitoyltransferase type-2 (CPT2) deficiency. We report the efficacy of fenofibrate in a patient with CPT2 deficiency, in whom beta-oxidation was improved but an episode of rhabdomyolysis nevertheless occurred. This suggests additional methods to avoid rhabdomyolysis in patients with CPT2 deficiency should accompany fibrate therapy, including avoidance of muscular overexertion, dehydration, and heat exposure.