Corneal Collagen Cross-Linking with Hypoosmolar Riboflavin Solution in Keratoconic Corneas. (14th August 2014)

• Record Type: Journal Article
• Authors: Gu, Shaofeng; Fan, Zhaoshan; Wang, Lihua; Tao, Xiangchen; Zhang, Yong; Mu, Guoying
• Other Names: Asimellis George Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-08-14
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/754182
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Purpose . To report the 12-month outcomes of corneal collagen cross-linking (CXL) with a hypoosmolar riboflavin and ultraviolet-A (UVA) irradiation in thin corneas. Methods . Eight eyes underwent CXL using a hypoosmolar riboflavin solution after epithelial removal. The corrected distance visual acuity (CDVA), manifest refraction, the mean thinnest corneal thickness (MTCT), and the endothelial cell density (ECD) were evaluated before and 6 and 12 months after CXL. Results . The MTCT was 413.9 ± 12.4 μ m before treatment and reduced to 381.1 ± 7.3 μ m after the removal of the epithelium. After CXL, the thickness decreased to 410.3 ± 14.5 μ m at the last follow-up. Before treatment, the mean K -value of the apex of the keratoconus corneas was 58.7 ± 3.5 diopters and slightly decreased (57.7 ± 4.9 diopters) at 12 months. The mean CDVA was 0.54 ± 0.23 logarithm of the minimal angle of resolution before treatment and increased to 0.51 ± 0.21 logarithm at the last follow-up. The ECD was 2731.4 ± 191.8 cells/mm 2 before treatment and was 2733.4 ± 222.6 cells/mm 2 at 12 months after treatment. Conclusions . CXL with a hypoosmolar riboflavin in thin corneas seems to be a promising method for keratoconic eyes with the mean thinnest corneal thickness less than 400 μ m without epithelium.