Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts. (17th February 2011)

• Record Type: Journal Article
• Authors: Calvo, Tamara Regina; Cardoso, Cássia Regina Primila; da Silva Moura, Adriana Candido; dos Santos, Lourdes Campaner; Colus, Ilce Mara Syllos; Vilegas, Wagner; Varanda, Eliana Aparecida
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2011(2011)
• Publication Date: 2011-02-17
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1093/ecam/nep123
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Indigofera truxillensis and I. suffruticosa, are used as a source of indigo dye and to treat several diseases. The mutagenic activity of the methanolic extracts from aerial parts, glycerolipid, flavonoid and alkaloid fractions of the extract were evaluated by means of Salmonella/ microsome assays using TA100, TA98, TA102 and TA97a strains. The methanolic extract of I. truxillensis showed mutagenic activity in the TA98 strain without S9 while glycerolipid fraction was devoid of activity. The flavonoid and alkaloid fractions of both plants showed mutagenicity. Chemical analysis of flavonoid fractions of I. truxillensis and I. suffruticosa resulted in the identification of kaempferol, quercetin and their derivatives. The alkaloid fraction of both the species contained indigo and indirubin and indigo was found mainly responsible for the mutagenic activity.