Effect of L. usitatissimum (Flaxseed/Linseed) Fixed Oil against Distinct Phases of Inflammation. (17th February 2013)

• Record Type: Journal Article
• Authors: Kaithwas, Gaurav; Majumdar, Dipak K.
• Other Names: Jalili A. Academic Editor.; Kim B. Academic Editor.; Szukiewicz D. Academic Editor.
• Is Part Of: ISRN inflammation. Volume 2013(2013)
• Publication Date: 2013-02-17
• Subjects: Inflammation -- Periodicals; Inflammation; Inflammation; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 616.0473
• DOI: 10.1155/2013/735158
• Languages: English
• ISSNs: 2090-8695

Abstract

Abstract : The present investigation summarizes the effect of Linum usitatissimum fixed oil against different phases of acute inflammatory reaction, namely, protein exudation, peritoneal capillary permeability, and leukocyte migration. The fixed oil exhibited dose-dependent inhibition of protein exudation vascular permeability, comparable to standard aspirin. The oil also inhibited the leukocyte migration in pleural exudates in a dose-dependent manner. Production of less vasodilatory (PGE3 ) and chemotactic (LTB5 ) eicosanoids through EPA (derived from linolenic acid) metabolism could account for the above observations.