Cover Feature: Fluorescent Indolo[3, 2‐a]phenazines against Toxoplasma gondii: Concise Synthesis by Gold‐Catalyzed Cycloisomerization with 1, 2‐Silyl Migration and ipso‐Iodination Suzuki Sequence (Chem. Eur. J. 38/2021). Issue 38 (14th June 2021)

• Record Type: Journal Article
• Authors: Merkt, Franziska K.; Mazzone, Flaminia; Sazzadeh, Shabnam Shaneh; Bonda, Lorand; Hinz, Larissa K. E.; Gruber, Irina; Buchholz, Karin; Janiak, Christoph; Pfeffer, Klaus; Müller, Thomas J. J.
• Is Part Of: Chemistry. Volume 27:Issue 38(2021)
• Page Start: 9717
• Page End: 9717
• Publication Date: 2021-06-14
• Subjects: bioactivity -- cycloisomerization -- heterocycles -- iodination -- multicomponent reactions -- Toxoplasma gondii; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202101939
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : New superheroes in town: Fluorescent Indolo[3, 2‐ a ]phenazines fight against T. gondii . Indolo[3, 2‐a]phenazines are a novel type of multifunctional heterocycle. They are tunable luminophores and highly biologically active. Furthermore, their photophysical characteristics correlate with Hammett σ p+ substituent parameters allowing finetuning of excited state properties such as emission maxima, Stokes shifts, and fluorescence quantum yields, by the remote para‐ aryl substitution. Best of all, they are highly active at low concentration against medically relevant pathogens such as the Apicomplexa parasite Toxoplasma gondii with IC50 up to 0.67±0.13μM. Therefore, these heterocyclic superheroes are promising bug fighters in novel anti‐parasitic therapies. More information can be found in the Full Paper by T. J. J. Müller et al. (DOI: 10.1002/chem.202101391 ).