CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors. (29th May 2014)

• Record Type: Journal Article
• Authors: Santoni, Matteo; Bracarda, Sergio; Nabissi, Massimo; Massari, Francesco; Conti, Alessandro; Bria, Emilio; Tortora, Giampaolo; Santoni, Giorgio; Cascinu, Stefano
• Other Names: Ping Yi-Fang Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-05-29
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/768758
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.