A new triterpenoid from the leaves of Rhodomyrtus tomentosa (Ait.) Hassk. Issue 14 (18th July 2021)

• Record Type: Journal Article
• Authors: Mo, Qinghu; Zhou, Xianli; Huang, Sixin; Zhou, Yun; Mou, Junfei; Luo, Qin; Huang, Xiao; Yang, Xinping; Chen, Xu; Liang, Chengqin
• Is Part Of: Natural product research. Volume 35:Issue 14(2021)
• Page Start: 2289
• Page End: 2294
• Publication Date: 2021-07-18
• Subjects: Myrtaceae -- Rhodomyrtus tomentosa -- triterpenoids -- α-glucosidase; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1670176
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new triterpenoid, 2 α, 3 β, 23 α, 29-tetrahydroxyolean-11, 13 (18)-dien-28, 19 β -olide, named as rhodotomoside A (1 ), together with six known triterpenoids (2–7 ), were isolated from the leaves of Rhodomyrtus tomentosa (Ait.) Hassk by column chromatography on silica gel, reversed-phase C18 silica gel and semi-preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods, including extensive 1D NMR, 2D NMR and MS spectra. The inhibition rates of α-glucosidase of compound 1 was 77.82%, and exhibited inhibitory activity against α-glucosidase with IC50 value at 0.213 ± 0.016 mg/mL. Graphical Abstract: