Noncoding RNAs: Emerging Players in Muscular Dystrophies. (4th March 2014)

• Record Type: Journal Article
• Authors: Falcone, Germana; Perfetti, Alessandra; Cardinali, Beatrice; Martelli, Fabio
• Other Names: Nakamura Akinori Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-03-04
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/503634
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and therapeutic targets.