SNP rs8099917 in Gene IL28B Might Be Associated with Risk of Chronic Infection by HCV but Not with Response to Treatment. (11th February 2014)

• Record Type: Journal Article
• Authors: da Silva Conde, Simone Regina Souza; Soares Monteiro, Julius Caesar Mendes; Silva dos Santos, Bruna Tereza; Fonseca Filgueiras, Nathália Karla; Almeida Lins, Pedro Alves de; Bonfim Freitas, Felipe; da Silva Graça, Ednelza; Demachki, Sâmia; Ferreira de Araújo, Marialva Tereza; Ishak, Ricardo; Rosário Vallinoto, Antonio Carlos
• Other Names: Quarleri Jorge Fabián Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-02-11
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/748606
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Aim . The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia. Methods . A total of 75 individuals with chronic hepatitis C and 98 healthy individuals from both genders over 18 years old were assessed. DNA samples were collected from leukocytes and subjected to real-time polymerase chain reaction to genotype polymorphisms rs12979860 and rs8099917. Results . Analysis of the allelic and genotypic frequencies of the investigated polymorphisms showed that both groups were in Hardy-Weinberg equilibrium; polymorphism rs12979860 exhibited no significant difference between the groups. For polymorphism rs8099917, allele T was significantly less frequent (P = 0.0195 ) among the patients (63.3%) than the controls (75.5%), and the patients were 1.7 times as likely to exhibit allele G. No difference in response to treatment was associated with SNP patterns. Conclusion . The results suggest a possible association of SNP rs8099917 with higher odds of chronic HCV infection but do not indicate a putative influence of the investigated SNPs on the sustained virologic response.