Iodine-Mediated Neutral and Selective N-Boc Deprotection. (27th June 2013)

• Record Type: Journal Article
• Authors: Pavan Kumar, G.; Rambabu, D.; Basaveswara Rao, M. V.; Pal, Manojit
• Other Names: Arslan Hakan Academic Editor.
• Is Part Of: Journal of chemistry. Volume 2013(2013)
• Publication Date: 2013-06-27
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1155/2013/916960
• Languages: English
• ISSNs: 2090-9063

Abstract

Abstract : A simple, efficient, and alternative method has been developed for the N -Boc deprotection of structurally diverse protected amines. Selective removal of N -Boc groups was achieved with excellent yields under a solvent-free condition or in a solvent using iodine as a catalyst. The methodology involving the first use of iodine for N -Boc deprotection of protected amines represents an effective and useful alternative to the previously reported methods.