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A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2, 4-dihydropyrano[2, 3-c]pyrazole-carbonitrile in Aqueous Medium. (27th September 2012)
Record Type:
Journal Article
Title:
A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2, 4-dihydropyrano[2, 3-c]pyrazole-carbonitrile in Aqueous Medium. (27th September 2012)
Main Title:
A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2, 4-dihydropyrano[2, 3-c]pyrazole-carbonitrile in Aqueous Medium
Abstract : A completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2, 4-dihydropyrano[2, 3- c ]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. Similar synthesis starting from aliphatic aldehydes was carried out in water: ethanol (1 : 1) at reflux temperature without using any catalyst.