Clinical and Pathological Features of Childhood-Onset Nemaline Myopathy: A Report of Four Cases. (31st July 2012)

• Record Type: Journal Article
• Authors: Jiang, Chao; Wang, Jianping; Lu, Haidong
• Other Names: de Carvalho Mamede Academic Editor.
• Is Part Of: Case reports in medicine. Volume 2012(2012)
• Publication Date: 2012-07-31
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Case Reports; Periodicals; 610
• DOI: 10.1155/2012/203602
• Languages: English
• ISSNs: 1687-9627

Abstract

Abstract : We examined whether immunological abnormalities can be found in the specimens of four childhood-onset nemaline myopathy (NM) patients without autoimmune diseases. Pathological examination revealed that nemaline rods were found in all specimens. The immunohistochemical results showed that CD4 positive cells and some other cells were gathered among the necrotic muscle fibers. We conclude that immunological abnormalities are present in the specimens of certain childhood-onset NM patients without autoimmune diseases. Further evaluation of the immunological changes is warranted in childhood-onset NM patients.