Evaluation of an Experimental Gel Containing Euclea natalensis: An In Vitro Study. (5th November 2012)

• Record Type: Journal Article
• Authors: Sales-Peres, Sílvia Helena de Carvalho; Brianezzi, Letícia Ferreira de Freitas; Marsicano, Juliane Avansini; Forim, Moacir Rossi; da Silva, Maria Fatima das Graças Fernandes; Sales-Peres, Arsenio
• Other Names: Pieroni Andrea Academic Editor.
• Is Part Of: Evidence-based complementary and alternative medicine. Volume 2012(2012)
• Publication Date: 2012-11-05
• Subjects: Alternative medicine -- Periodicals; 615.505
• DOI: 10.1155/2012/184346
• Languages: English
• ISSNs: 1741-427X

Abstract

Abstract : Objective . To evaluate the effect of an experimental gel containing Euclea natalensis extract on dentin permeability. Methods . Thirty-six dentin discs, 1-mm-thick. The discs were prepared from the coronal dentin of extracted human third molars that were divided into 3 groups (n = 10 ). The dentin discs in each group were treated with the groups following experimental materials: (FG): 1.23% fluoride gel, pH 4.1; (EG): Euclea natalensis extract gel, pH 4.1; (CG): control gel, pH 4.1. The gels were applied to the occlusal slide of the dentin under the following conditions: after 37% phosphoric acid and before 6% citric acid. The hydraulic conductance (HC) of each condition was determined four times using a fluid flow apparatus (Flodec). The data were analyzed using Two-way ANOVA and Tukey's test (P < 0.05 ). Results . The greatest mean reduction in HC was produced in group EG dentin discs (61.2%; P < 0.05 ). Even after acid challenge with 6% citric acid the great reduction occurred in group EG (66.0%; P < 0.05 ) than other groups (CG-77.1%, FG-90.8%). Conclusion . E. natalensis gel not only reduced dentin permeability, but also resisted posttreatment citric acid challenge without changing its permeability. Further research has to confirm this promising result in the clinical situation.