Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42 to the Rat Brain. (23rd June 2014)

• Record Type: Journal Article
• Authors: Borbély, Emőke; Horváth, János; Furdan, Szabina; Bozsó, Zsolt; Penke, Botond; Fülöp, Lívia
• Other Names: Chang Raymond Chuen-Chung Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-06-23
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/345305
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Several animal models of Alzheimer's disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fA β ) peptide represents one of the most frequently used models, mimicking A β deposits in the brain. In our experiment synthetic fA β 1–42 peptide was administered to rat hippocampus. The effect of the A β peptide on spatial memory and dendritic spine density was studied. The fA β 1–42 -treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fA β 1–42 caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying A β -triggered neurodegeneration processes.