Investigation of NF-κB1 and NF-κBIA Gene Polymorphism in Non-Small Cell Lung Cancer. (23rd February 2014)

• Record Type: Journal Article
• Authors: Oltulu, Y. M.; Coskunpinar, E.; Ozkan, G.; Aynaci, E.; Yildiz, P.; Isbir, T.; Yaylim, I.
• Other Names: Sharma Sherven Academic Editor.
• Is Part Of: BioMed research international. Volume 2014(2014)
• Publication Date: 2014-02-23
• Subjects: Medicine -- Periodicals; Biology -- Periodicals; Biotechnology -- Periodicals; Life sciences -- Periodicals; 610.5
• DOI: 10.1155/2014/530381
• Languages: English
• ISSNs: 2314-6133

Abstract

Abstract : Lung cancer is a complex, multifactorial disease which is the leading cause of cancer death in both men and women. NF- κ B is a transcription factor which is known to affect the expression of more than 150 genes related to inflammation, lymphocyte activation, cell proliferation, differentiation, and apoptosis, as well as contributing to cell apoptosis and survival. However, NF- κ BIA (I κ B α ) is the inhibitor of the transcription factor. The -94ins/delATTG polymorphism of the NF- κ B1 gene promoter region which causes a functional effect and NF- κ BIA 3′UTR A → G polymorphism has been shown to be related to various inflammatory diseases and cancer. Ninety-five NSCLC patients and 99 healthy controls were included in study. The NF- κ B1 -94ins/delATTG and NF- κ BIA 3′UTR A → G polymorphism have been studied by using PCR-RFLP method. It was found that the NF- κ B1 -94ins/delATTG DD genotype and D allele frequencies were higher in patients than healthy controls and the presence of the DD genotype has a 3.5-fold increased risk of the disease ( P : 0.014). This study is the first to investigate the NF- κ B1 -94ins/delATTG and NF- κ BIA 3′UTR A → G polymorphism together in the Turkish population. According to the results, the NF- κ B1 -94ins/del ATTG promoter polymorphism may have a role in lung carcinogenesis and prognosis.