Nrf2‐interacting nutrients and COVID‐19: time for research to develop adaptation strategies. Issue 1 (3rd December 2020)

• Record Type: Journal Article
• Authors: Bousquet, Jean; Cristol, Jean‐Paul; Czarlewski, Wienczyslawa; Anto, Josep M.; Martineau, Adrian; Haahtela, Tari; Fonseca, Susana C.; Iaccarino, Guido; Blain, Hubert; Fiocchi, Alessandro; Canonica, G. Walter; Fonseca, Joao A.; Vidal, Alain; Choi, Hak‐Jong; Kim, Hyun Ju; Le Moing, Vincent; Reynes, Jacques; Sheikh, Aziz; Akdis, Cezmi A.; Zuberbier, Torsten; Abdul Latiff, Amir Hamzah; Abdullah, Baharudin; Aberer, Werner; Abusada, Nancy; Adcock, Ian; Afani, Alejandro; Agache, Ioana; Aggelidis, Xenofon; Agustin, Jenifer; Akdis, Cezmi A; Akdis, Mübeccel; Al‐Ahmad, Mona; Al‐Zahab Bassam, Abou; Alburdan, Hussam; Aldrey‐Palacios, Oscar; Alvarez Cuesta, Emilio; Alwan Salman, Hiba; Alzaabi, Ashraf; Amade, Salma; Ambrocio, Gene; Angles, Rosana; Annesi‐Maesano, Isabella; Ansotegui, Ignacio J; Anto, Josep M.; Ara Bardajo, Paula; Arasi, Stefania; Arrais, Margarete; Arshad, Hasan; Artesani, Maria‐Cristina; Asayag, Estrella; Avolio, Francesca; Azhari, Khuzama; Bachert, Claus; Bagnasco, Diego; Baiardini, Ilaria; Bajrović, Nissera; Bakakos, Petros; Bakeyala Mongono, Sergio; Balotro‐Torres, Christine; Barba, Sergio; Barbara, Cristina; Barbosa, Elsa; Barreto, Bruno; Bartra, Joan; Basagana, Xavier; Bateman, Eric D.; Battur, Lkhagvaa; Bedbrook, Anna; Bedolla Barajas, Martín; Beghé, Bianca; Bekere, Antra; Bel, Elizabeth; Ben Kheder, Ali; Benson, Mikael; Berghea, Elena‐Camelia; Bergmann, Karl‐Christian; Bernardini, Roberto; Bernstein, David; Bewick, Mike; Bialek, Slawomir; Białoszewski, Artur; Bieber, Thomas; Billo, Nils E.; Bilo, Maria‐Beatrice; Bindslev‐Jensen, Carsten; Bjermer, Leif; Blain, Hubert; Bobolea, Irina; Bochenska Marciniak, Malgorzata; Bond, Christine; Boner, Attilio; Bonini, Matteo; Bonini, Sergio; Bosnic‐Anticevich, Sinthia; Bosse, Isabelle; Botskariova, Sofia; Bouchard, Jacques; Boulet, Louis‐Philippe; Bourret, Rodolphe; Bousquet, Philippe; Braido, Fulvio; Briggs, Andrew; Brightling, Christopher E; Brozek, Jan; Brussino, Luisa; Buhl, Roland; Bumbacea, Roxana; Buquicchio, Rosalva; Burguete Cabañas, María‐Teresa; Bush, Andrew; Busse, William W; Buters, Jeroen; Caballero‐Fonseca, Fernan; Calderon, Moïses A; Calvo, Mario; Camargos, Paulo; Camuzat, Thierry; Canevari, FR; Cano, Antonio; Canonica, G. Walter; Capriles‐Hulett, Arnaldo; Caraballo, Luis; Cardona, Vicky; Carlsen, Kai‐Hakon; Carmona Pirez, Jonas; Caro, Jorge; Carr, Warner; Carreiro‐Martins, Pedro; Carreon‐Asuncion, Fredelita; Carriazo, Ana‐Maria; Carrion y Ribas, Carme; Casale, Thomas; Castor, Mary‐Ann; Castro, Elizabeth; Caviglia, A. G.; Cecchi, Lorenzo; Cepeda Sarabia, Alfonso; Chalubinski, Maciej; Chandrasekharan, Ramanathan; Chang, Yoon‐Seok; Chato‐Andeza, Victoria; Chatzi, Lida; Chatzidaki, Christina; Chavannes, Niels H.; Chaves Loureiro, Claudia; Chavez Garcia, Aurora‐Alejandra; Chelninska, Marta; Chen, Yuzhi; Cheng, Lei; Chinthrajah, Sharon; Chivato, Tomas; Chkhartishvili, Ekaterine; Christoff, George; Chrystyn, Henry; Chu, Derek K; Chua, Antonio; Chuchalin, Alexander; Chung, Kian Fan; Cicerán, Alberto; Cingi, Cemal; Ciprandi, Giorgio; Cirule, Ieva; Coelho, Ana‐Carla; Compalati, Enrico; Constantinidis, Jannis; Correia de Sousa, Jaime; Costa, Elisio Manuel; Costa, David; del Carmen Costa Domínguez, María; Coste, André; Cottini, M.; Cox, Linda; Crisci, Carlos; Crivellaro, Maria Angiola; Cruz, Alvaro A; Cullen, John; Custovic, Adnan; Cvetkovski, Biljana; Czarlewski, Wienczyslawa; D'Amato, Gennaro; da Silva, Jane; Dahl, Ronald; Dahlen, Sven‐Erik; Daniilidis, Vasilis; Darjazini Nahhas, Louei; Darsow, Ulf; Davies, Janet; de Blay, Frédéric; De Feo, Giulia; De Guia, Eloisa; De la Torre Navarrete, José‐Ricardo; De los Santos, Chato; De Manuel Keenoy, Esteban; De Vries, Govert; Deleanu, Diana; Demoly, Pascal; Denburg, Judah; Devillier, Philippe; Didier, Alain; Dimic Janjic, Sanja; Dimou, Maria; Dinh‐Xuan, Anh Tuan; Djukanovic, Ratko; Do Ceu Texeira, Maria; Dokic, Dejan; Domínguez Silva, Margarita Gabriela; Douagui, Habib; Douladiris, Nikolaos; Doulaptsi, Maria; Dray, Gérard; Dubakiene, Ruta; Dupas, Eve; Durham, Stephen; Duse, Marzia; Dykewicz, Mark; Ebo, Didier; Edelbaher, Natalija; Eiwegger, Thomas; Eklund, Patrik; El‐Gamal, Yehia; El‐Sayed, Zeinab A.; El‐Sayed, Shereen S.; El‐Seify, Magda; Emuzyte, Regina; Enecilla, Lourdes; Erhola, Marina; Espinoza, Heidilita; Espinoza Contreras, Jesús Guillermo; Farrell, John; Fernandez, Lenora; Fimbres Jimenez, Paola; Fink Wagner, Antje; Fiocchi, Alessandro; Fokkens, Wytske J; Folletti, Lenia; Fonseca, Joao A; Fontaine, Jean‐François; Forastiere, Francesco; Fuentes Pèrez, Jose Miguel; Gaerlan‐Resureccion, Emily; Gaga, Mina; Gálvez Romero, José Luis; Gamkrelidze, Amiran; Garcia, Alexis; García Cobas, Cecilia Yvonne; de la Luz Hortensia García Cruz, María; Ortiz, Valeria Garcia; Gayraud, Jacques; Gelardi, Matteo; Gemicioglu, Bilun; Gennimata, Dimitra; Genova, Sonya; Gereda, José; Gerth van Wijk, Roy; Giuliano, Antonio; Gomez, René‐Maximiliano; Gonzalez Ballester, Miguel‐Ange; González Diaz, Sandra; Gotua, Maia; Grigoreas, Christos; Grisle, Ineta; Guidacci, Marta; Guldemond, Nick; Gutter, Zdenek; Guzmán, Antonieta; Haahtela, Tari; Halloum, Ramsa; Halpin, David; Hamelmann, Eckard; Hammadi, Suleiman; Harvey, Richard; Heffler, Enrico; Heinrich, Joachim; Hejjaoui, Adnan; Hellquist‐Dahl, Birthe; Hernández Velázquez, Luiana; Hew, Mark; Hossny, Elham; Howarth, Peter; Hrubiško, Martin; Huerta Villalobos, Yunuen Rocío; Humbert, Marc; Husain, Salina; Hyland, Michael; Iaccarino, Guido; Ibrahim, Moustafa; Ilina, Nataliya; Illario, Maddalena; Incorvaia, Cristoforo; Infantino, Antonio; Irani, Carla; Ispayeva, Zhanat; Ivancevich, Juan Carlos; Jares, Edgardo EJ; Jarvis, Deborah; Jassem, Ewa; Jenko, Klemen; Jiméneracruz Uscanga, Rubén Darío; Johnston, Sebastian L; Joos, Guy; Jošt, Maja; Julge, Kaja; Jung, Ki‐Suck; Just, Jocelyne; Jutel, Marek; Kaidashev, Igor; Kalayci, Omer; Kalyoncu, Fuat; Kapsali, Jeni; Kardas, Przemyslaw; Karjalainen, Jussi; Kasala, Carmela A.; Katotomichelakis, Michael; Kavaliukaite, Loreta; Bennoor, Kazi S.; Keil, Thomas; Keith, Paul; Khaitov, Musa; Khaltaev, Nikolai; Kim, You‐Young; Kirenga, Bruce; Kleine‐Tebbe, Jorg; Klimek, Ludger; Ko, Fanny W.; Koffi N'Goran, Bernard; Kompoti, Evangelia; Kopač, Peter; Koppelman, Gerard; Koren Jeverica, Anja; Koskinen, Seppo; Košnik, Mitja; Kostka, Tomasz; Kostov, Kosta V.; Kowalski, Marek L; Kralimarkova, Tanya; Kramer Vrščaj, Karmen; Kraxner, Helga; Kreft, Samo; Kritikos, Vicky; Kudlay, Dmitry; Kuitunen, Mikael; Kull, Inger; Kuna, Piotr; Kupczyk, Maciej; Kvedariene, Violeta; Kyriakakou, Marialena; Lalek, Nika; Landi, Massimo; Lane, Stephen; Larenas‐Linnemann, Désiree E.; Lau, Susanne; Laune, Daniel; Lavrut, Jorge; Le, Lan; Lenzenhuber, Martina; Leo, Gualtiero; Lessa, Marcus; Levin, Michael; Li, Jing; Lieberman, Philip; Liotta, Giuseppe; Lipworth, Brian; Liu, Xuandao; Lobo, Rommel; Lodrup Carlsen, Karin C; Lombardi, Carlo; Louis, Renaud; Loukidis, Stelios; Lourenço, Olga; Luna Pech, Jorge A.; Madjar, Bojan; Maggi, Enrico; Magnan, Antoine; Mahboub, Bassam; Mair, Alpana; Maitland van der Zee, Anke‐Hilse; Makela, Mika; Makris, Michael; Malling, Hans‐Jorgen; Mandajieva, Mariana; Manning, Patrick; Manousakis, Manolis; Maragoudakis, Pavlos; Marseglia, Gianluigi; Marshall, Gailen; Masjedi, Mohammad Reza; Máspero, Jorge F.; Matta Campos, Juan José; Maurer, Marcus; Mavale‐Manuel, Sandra; Meço, Cem; Melén, Erik; Melioli, Giovanni; Melo‐Gomes, Elisabete; Meltzer, Eli O; Menditto, Enrica; Menzies‐Gow, Andrew; Merk, Hans; Michel, Jean‐Pierre; Micheli, Yann; Miculinic, Neven; Midão, Luís; Mihaltan, Florin; Mikos, Nikolaos; Milanese, Manlio; Milenkovic, Branislava; Mitsias, Dimitrios; Moalla, Bassem; Moda, Giuliana; Mogica Martínez, María Dolores; Mohammad, Yousser; Moharra, Frances‐Montserrat; Moin, Mostafa; Molimard, Mathieu; Momas, Isabelle; Mommers, Monique; Monaco, Alessandro; Montefort, Stephen; Montenegro, Lucia‐Elvira; Monti, Riccardo; Mora, Dory; Morais‐Almeida, Mario; Mösges, Ralph; Mostafa, Badr Eldin; Mullol, Joaquim; Münter, Lars; Muraro, Antonella; Murray, Ruth; Musarra, Antonio; Mustakov, Tihomir; Naclerio, Robert; Nadeau, Kari C.; Nadif, Rachel; Nakonechna, Alla; Namazova‐Baranova, Leyla; Navarro‐Locsin, Gretchen; Neffen, Hugo; Nekam, Kristof; Neou, Angelos; Nettis, Eustachio; Neuberger, Daniel; Nicod, Laurent; Nicola, Stefania; Niederberger‐Leppin, Verena; Niedoszytko, Marek; Nieto, Antonio; Novellino, Ettore; Nunes, Elizabete; Nyembue, Dieudonné; O'Hehir, Robyn E.; Odjakova, Cvetanka; Ohta, Ken; Okamoto, Yoshitaka; Okubo, Kimi; Oliver, Brian; Onorato, Gabrielle L; Orru, Maria Pia; Ouédraogo, Solange; Ouoba, Kampadilemba; Padilla, Francisco‐Javier; Paggiaro, Pier Luigi; Pagkalos, Aris; Pajno, Giovanni; Pala, Gianni; Palaniappan, SP; Pali‐Schöll, Isabella; Palkonen, Susanna; Palmer, Stephen; Panaitescu Bunu, Carmen; Panzner, Petr; Papadopoulos, Nikos G; Papanikolaou, Vasilis; Papi, Alberto; Paralchev, Bojidar; Paraskevopoulos, Giannis; Park, Hae‐Sim; Passalacqua, Giovanni; Patella, Vincenzo; Pavord, Ian; Pawankar, Ruby; Pedersen, Soren; Peleve, Susete; Pellegino, Simona; Pereira, Ana; Pereira, Mariana; Pérez, Tamara; Perna, Andrea; Peroni, Diego; Pfaar, Oliver; Pham‐Thi, Nhân; Pigearias, Bernard; Pin, Isabelle; Piskou, Konstantina; Pitsios, Constantinos; Plavec, Davor; Poethig, Dagmar; Pohl, Wolfgang; Poplas Susic, Antonija; Popov, Todor A.; Portejoie, Fabienne; Potter, Paul; Poulsen, Lars; Prados‐Torres, Alexandra; Prarros, Fotis; Price, David; Prokopakis, Emmanuel; Puggioni, Francesca; Puig‐Domenech, Elisa; Puy, Robert; Rabe, Klaus; Rabotti, Silvia; Raciborski, Filip; Ramos, Josephine; Recalcati, Cristina; Recto, Marysia T.; Reda, Shereen M.; Regateiro, Frederico S; Reider, Norbert; Reitsma, Sietze; Repka‐Ramirez, Susana; Ridolo, Erminia; Rimmer, Janet; Rivero Yeverino, Daniela; Rizzo, José Angelo; Robalo‐Cordeiro, Carlos; Roberts, Graham; Robles, Karen; Roche, Nicolas; Rodríguez González, Mónica; Rodríguez Zagal, Eréndira; Rolla, Giovanni; Rolland, Christine; Roller‐Wirnsberger, Regina; Roman Rodriguez, Miguel; Romano, Antonino; Romantowski, Jan; Rombaux, Philippe; Romualdez, Joel; Rosado‐Pinto, Jose; Rosario, Nelson; Rosenwasser, Lanny; Rossi, Oliviero; Rottem, Menachem; Rouadi, Philip W.; Rovina, Nikoleta; Rozman Sinur, Irma; Ruiz, Mauricio; Ruiz Segura, Lucy Tania; Ryan, Dermot; Sagara, Hironori; Sakai, Daiki; Sakurai, Daiju; Saleh, Wafaa; Salimaki, Johanna; Samitas, Konstantinos; Samolinski, Boleslaw; Sánchez Coronel, María Guadalupe; Sanchez‐Borges, Mario; Sanchez‐Lopez, Jaime; Sansonna, Melissa; Sarafoleanu, Codrut; Sarquis Serpa, Faradiba; Sastre, Joaquin; Savi, Eleonora; Savonyte, Agne; Sawaf, Bisher; Scadding, Glenis K; Scheire, Sophie; Schmid‐Grendelmeier, Peter; Schuhl, Juan Francisco; Schunemann, Holger; Schvalbová, Maria; Schwarze, Jorgen; Scichilone, Nicola; Senna, Gianenrico; Sepúlveda, Cecilia; Serrano, Elie; Shamai, Sara; Sheikh, Aziz; Shields, Mike; Shishkov, Vasil; Siafakas, Nikos; Simeonov, Alexander; Simons, Estelle FER; Sisul, Juan Carlos; Sitkauskiene, Brigita; Skrindo, Ingelbjorg; Soklič Košak, Tanja; Solé, Dirceu; Sondermann, Martin; Sooronbaev, Talant; Soto‐Martinez, Manuel; Soto‐Quiros, Manuel; Pinto, Barnaro Sousa; Sova, Milan; Soyka, Michael; Specjalski, Krzysztof; Sperl, Annette; Spranger, Otto; Stamataki, Sofia; Stefanaki, Lina; Stellato, Cristiana; Stelmach, Rafael; Strandberg, Timo; Stute, Petra; Subramaniam, Abirami; Suppli Ulrik, Charlotte; Sutherland, Michael; Sylvestre, Silvia; Syrigou, Aikaterini; Taborda Barata, Luis; Takovska, Nadejda; Tan, Rachel; Tan, Frances; Tan, Vincent; Tang, Ing Ping; Taniguchi, Masami; Tannert, Line; Tantilipikorn, Pongsakorn; Tattersall, Jessica; Tesi, Filippo; Thieme, Uta; Thijs, Carel; Thomas, Mike; To, Teresa; Todo‐Bom, Ana Maria; Togias, Alkis; Tomazic, Peter‐Valentin; Tomic‐Spiric, Vesna; Toppila‐Salmi, Sanna; Torres Jaen, Maria‐José; Toskala, Elina; Triggiani, Massimo; Triller, Nadja; Triller, Katja; Tsiligianni, Ioanna; Uberti, M.; Ulmeanu, Ruxandra; Urbancic, Jure; Urrutia Pereira, Marilyn; Vachova, Martina; Valdés, Felipe; Valenta, Rudolf; Valentin Rostan, Marylin; Valero, Antonio; Valiulis, Arunas; Vallianatou, Mina; Valovirta, Erkka; Van Eerd, Michiel; Van Ganse, Eric; van Hage, Marianne; Vandenplas, Olivier; Vasankari, Tuula; Vassileva, Dafina; Velasco Munoz, Cesar; Ventura, Maria Teresa; Vera‐Munoz, Cécilia; Viart, Frédéric; Vicheva, Dilyana; Vichyanond, Pakit; Vidgren, Petra; Viegi, Giovanni; Vogelmeier, Claus; Von Hertzen, Leena; Vontetsianos, Theodoros; Vourdas, Dimitris; Tran Thien Quan, Vu; Wagenmann, Martin; Walker, Samantha; Wallace, Dana; De Wang, Yun; Waserman, Susan; Wehner, Katrin; Wickman, Magnus; Williams, Sian; Williams, Dennis; Wilson, Nicola; Wong, Gary; Woo, Kent; Wozniak, Lucyna; Wright, John; Wroczynski, Piotr; Xepapadaki, Paraskevi; Yakovliev, Plamen; Yamaguchi, Masao; Yan, Kwok; Yap, Yoke Yeow; Yassin, Mais; Yawn, Barbara; Yiallouros, Panayiotis; Yorgancioglu, Arzu; Yoshihara, Shigemi; Young, Ian; Yusuf, Osman B; Zaidi, Asghar; Zaitoun, Fares; Zalud, Petra; Zar, Heather; Zedda, M. T.; Zernotti, Mario E; Zhang, Luo; Zhong, Nanshan; Zidarn, Mihaela; Zuberbier, Torsten; Zubrinich, Celia;
• Is Part Of: Clinical and translational allergy. Volume 10:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-03
• Subjects: COVID‐19 -- Nrf2 -- Foods -- Nutrients -- Insulin resistance -- Obesity -- TRPA1; Allergy -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Hypersensitivity -- Periodicals; Immune System Phenomena -- Periodicals; 616.97005
• DOI: 10.1186/s13601-020-00362-7
• Languages: English
• ISSNs: 2045-7022

Abstract

Abstract: There are large between‐ and within‐country variations in COVID‐19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid‐derived 2)‐like 2) anti‐oxidant transcription factor. There are many Nrf2‐interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator‐activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal‐regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID‐19, acting through the endoplasmic reticulum stress or ACE‐Angiotensin‐II‐AT1 R axis (AT1 R) pathway. Many Nrf2‐interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID‐19 mortality are those with the lowest prevalence of obesity (Sub‐Saharan Africa and Asia). It is tempting to propose that Nrf2‐interacting foods and nutrients can re‐balance insulin resistance and have a significant effect on COVID‐19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID‐19 severity.