Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort. Issue 1 (11th February 2019)

• Record Type: Journal Article
• Authors: Raciborski, Filip; Bousqet, Jean; Namysłowski, Andrzej; Krzych‐Fałta, Edyta; Tomaszewska, Aneta; Piekarska, Barbara; Samel‐Kowalik, Piotr; Białoszewski, Artur Z.; Walkiewicz, Artur; Lipiec, Agnieszka; Wojas, Oksana; Samoliński, Krzysztof; Szylling, Anna; Zieliński, Wojciech; Sybilski, Adam; Grąbczewska, Aleksandra; Samoliński, Bolesław
• Is Part Of: Clinical and translational allergy. Volume 9:Issue 1(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-02-11
• Subjects: Muitimorbidity -- Polysensitization -- IgE -- Skin tests -- Allergy -- Asthma -- Rhinitis -- Urticaria -- Atopic dermatitis; Allergy -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Hypersensitivity -- Periodicals; Immune System Phenomena -- Periodicals; 616.97005
• DOI: 10.1186/s13601-019-0246-y
• Languages: English
• ISSNs: 2045-7022

Abstract

Abstract: Background: Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity. Material and method: A cross‐sectional multicentre study enrolled children aged 6–7 and 13–14 years and adults aged 20–44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested. Results: Among the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and allergic multimorbidity in 9.3%. Allergic multimorbidity occurred more commonly in children than in adults (p < 0.01). Asthma or atopic dermatitis alone were not associated with polysensitization. Rhinitis and multimorbidity were associated with polysensitization. Allergic multimorbidity occurred in 2.2% of participants with negative skin prick tests, 9.8% of those with one positive prick test (SPT ≥ 3 mm) and 20.6% of polysensitized ones (p < 0.001). There was an increasing risk of multimorbidity depending on the number of positive prick tests for both SPT ≥ 3 mm (OR 9.6–16.5) and SPT ≥ 6 mm (OR 5.9–13.7). A statistically significant relationship was found between allergic multimorbidity and sensitization to cat and mite allergens. Conclusions: Multimorbidity is associated with polysensitization especially in children compared with adults in Polish population cohort. New insights into single disease patterns were found: bronchial asthma is the strongest risk factor for the development of multimorbidity in comparison with allergic rhinitis and atopic dermatitis.