Cough hypersensitivity as a neuro‐immune interaction. Issue 1 (15th July 2015)

• Record Type: Journal Article
• Authors: Song, Woo‐Jung; Chang, Yoon‐Seok
• Is Part Of: Clinical and translational allergy. Volume 5:Issue 1(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-07-15
• Subjects: Cough -- Hypersensitivity -- Immune -- Neuron -- Interaction; Allergy -- Periodicals; Immunology -- Periodicals; Allergy and Immunology -- Periodicals; Hypersensitivity -- Periodicals; Immune System Phenomena -- Periodicals; 616.97005
• DOI: 10.1186/s13601-015-0069-4
• Languages: English
• ISSNs: 2045-7022

Abstract

Abstract: Cough is an intrinsic protective reflex. However, chronic cough affects a considerable proportion of general population and has a major impact on quality of life. A recent paradigm shift to 'cough hypersensitivity syndrome' suggests that chronic cough arises from hypersensitivity of the airway sensory nerves. As cough reflex is determined by interaction of the nervous system with immune system, persistent dysregulation of one or both of these systems may lead to chronic cough hypersensitivity. Here we review the current evidence for the neuro‐immune interactions that underlie cough hypersensitivity and discuss future therapeutic strategies.