Association of ERCC1 SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study. (November 2012)

• Record Type: Journal Article
• Authors: Nikitas, Nikitas; Karadimou, Alexandra; Tsitoura, Eliza; Soupos, Nikolaos; Tsiatas, Marinos; Karavasilis, Vasilios; Pectasides, Dimitrios; Pavlidis, Nikolaos; Chrisofos, Michael; Adamakis, Ioannis; Murray, Samuel; Fountzilas, Georgios; Dimopoulos, Meleios-Athanasios; Bamias, Aristotle
• Is Part Of: Pharmacogenomics. Volume 13:Number 14(2012)
• Page Start: 1595
• Page End: 1607
• Publication Date: 2012-11
• Subjects: cisplatin -- human ERCC1 gene -- nucleotide excision repair -- single-nucleotide polymorphism -- urothelial cancer; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.12.162
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: The association between two polymorphisms of ERCC1 and treatment outcomes after platinum-based chemotherapy in patients with advanced urothelial cancer (UC) was examined.Materials & methods: Genotyping of 19007C>T and 8092C>A polymorphisms was determined by PCR amplification and RFLP in 113 advanced UC patients, treated with platinum-based chemotherapy.Results: Seventy eight patients (69%) were carriers of the 19007T polymorphic allele: 51 (45%) heterozygotes and 27 (24%) homozygotes. Fifty three (47%) patients were carriers of the 8092A polymorphic allele: the frequencies of C/A and A/A genotypes were 37% and 10%, respectively. The T/T genotype was independently associated with prolonged median cancer-specific survival (not-reached vs 14.8 months; p = 0.026). There was no interaction between T/T or any other genotype with the type of platinum derivative (cisplatin/carboplatin).Conclusion: 19007C>T, especially in its homozygotic state, but not 8092C>A polymorphism, could be a useful prognostic marker in advanced UC treated with platinum-based chemotherapy. Original submitted 17 July 2012; Revision submitted 21 September 2012