Small rings in the bigger picture: ring expansion of three- and four-membered rings to access larger all-carbon cyclic systems. (18th May 2021)

• Record Type: Journal Article
• Authors: Biletskyi, Bohdan; Colonna, Pierre; Masson, Kévin; Parrain, Jean-Luc; Commeiras, Laurent; Chouraqui, Gaëlle
• Is Part Of: Chemical Society reviews. Volume 50:Number 13(2021)
• Page Start: 7513
• Page End: 7538
• Publication Date: 2021-05-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cs01396j
• Languages: English
• ISSNs: 0306-0012

Abstract

Abstract : Ring-expansion of strained small-size rings to forge larger all-carbon ones, allows a rapid build-up of molecular complexity. Abstract : The release of the inherent ring strain of cyclobutane and cyclopropane derivatives allows a rapid build-up of molecular complexity. This review highlights the state-of-the-art of the ring expansions of three- and four-membered cycles and is organised by types of reactions with emphasis on the reaction mechanisms. Selected examples are discussed to illustrate the synthetic potential of this elegant synthetic tool.