Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta‐analysis. Issue 8 (17th June 2019)

• Record Type: Journal Article
• Authors: Tian, Jiaxing; Jin, De; Bao, Qi; Ding, Qiyou; Zhang, Haiyu; Gao, Zezheng; Song, Juexian; Lian, Fengmei; Tong, Xiaolin
• Is Part Of: Diabetes, obesity & metabolism. Volume 21:Issue 8(2019)
• Page Start: 1801
• Page End: 1816
• Publication Date: 2019-06-17
• Subjects: diabetes -- diabetic complications -- pharmacological mechanisms -- prediabetes -- randomized controlled trials -- traditional Chinese medicine; Diabetes -- Periodicals; Obesity -- Periodicals; Metabolism -- Disorders -- Periodicals; Clinical pharmacology -- Periodicals; 616.462
• DOI: 10.1111/dom.13760
• Languages: English
• ISSNs: 1462-8902

Abstract

Abstract: Traditional Chinese medicine (TCM) has recorded knowledge of diabetes for over 2000 years. Because a considerable number of TCM studies exhibit design defects, such as limited intervention duration, small sample sizes and inconsistent efficacy evaluations, the role of TCM in the treatment of diabetes cannot be fully elucidated. In this review, we evaluate randomized controlled trials of prediabetes, diabetes and diabetic complications published in the past decade. We found that TCM could significantly improve glucose control and clinical indices in patients with diabetes and effectively delay the progression of diabetes. We also summarize potential pharmacological mechanisms underlying the efficacy of TCM medication/herbs and their active ingredients for treating diabetes. More rigorously designed experiments and long‐term evaluation of TCM for diabetes will allow for more effective diabetes management.