Epstein–Barr virus positivity among surgically resected intramucosal gastric cancer. Issue 5 (6th June 2018)

• Record Type: Journal Article
• Authors: Murai, Katsuyuki; Kakushima, Naomi; Sugino, Takashi; Yoshida, Masao; Kawata, Noboru; Tanaka, Masaki; Takizawa, Kohei; Muramatu, Koji; Kusafuka, Kimihide; Bando, Etsuro; Ono, Hiroyuki
• Is Part Of: Digestive endoscopy. Volume 30:Issue 5(2018)
• Page Start: 667
• Page End: 671
• Publication Date: 2018-06-06
• Subjects: Epstein–Barr virus infection -- lace pattern -- lymph node metastasis -- lymphocyte infiltration -- stomach neoplasm; Digestive organs -- Diseases -- Periodicals; Digestive organs -- Diseases -- Diagnosis -- Periodicals; Endoscopy -- Periodicals; Digestive System Diseases -- diagnosis -- Periodicals; Digestive System Diseases -- therapy -- Periodicals; Endoscopy -- Periodicals; 616.3
• DOI: 10.1111/den.13181
• Languages: English
• ISSNs: 0915-5635

Abstract

Abstract : Epstein–Barr virus‐associated gastric cancer (EBV‐GC) accounts for approximately 8% of gastric cancers. However, little is known regarding intramucosal EBV‐GC. The present study aimed to evaluate endoscopic and clinicopathological characteristics of intramucosal EBV‐GC. Pathological data of 172 patients with 173 intramucosal gastric cancers who received gastrectomy with lymph node dissection were obtained for review. EBV‐encoded small RNA in situ hybridization (EBER‐ISH) was carried out using a tissue microarray block. Eight intramucosal early gastric cancers (4.6%) were EBER‐ISH positive in which no cases had any lymph node metastasis. Macroscopic types were either depressed or flat, dominant histology was mixed type of moderate and poorly differentiated adenocarcinoma. In detail, histological features of "lace pattern" or "lymphocyte infiltration into the stroma or cancer nests" were observed.