Impact of aspirin on takotsubo syndrome: a propensity score‐based analysis of the InterTAK Registry. (20th December 2019)

• Record Type: Journal Article
• Authors: D'Ascenzo, Fabrizio; Gili, Sebastiano; Bertaina, Maurizio; Iannaccone, Mario; Cammann, Victoria L.; Di Vece, Davide; Kato, Ken; Saglietto, Andrea; Szawan, Konrad A.; Frangieh, Antonio H.; Boffini, Beatrice; Annaratone, Margherita; Sarcon, Annahita; Levinson, Rena A.; Franke, Jennifer; Napp, L. Christian; Jaguszewski, Milosz; Noutsias, Michel; Münzel, Thomas; Knorr, Maike; Heiner, Susanne; Katus, Hugo A.; Burgdorf, Christof; Schunkert, Heribert; Thiele, Holger; Bauersachs, Johann; Tschöpe, Carsten; Pieske, Burkert M.; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Hasenfuß, Gerd; Karakas, Mahir; Koenig, Wolfgang; Rottbauer, Wolfgang; Said, Samir M.; Braun‐Dullaeus, Ruediger C.; Banning, Adrian; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A.; Vasankari, Tuija; Airaksinen, K.E. Juhani; Opolski, Grzegorz; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Franz, Wolfgang M.; Empen, Klaus; Felix, Stephan B.; Delmas, Clément; Lairez, Olivier; El‐Battrawy, Ibrahim; Akin, Ibrahim; Borggrefe, Martin; Horowitz, John D.; Kozel, Martin; Tousek, Petr; Widimský, Petr; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Biondi‐Zoccai, Giuseppe; Winchester, David E.; Ukena, Christian; Neuhaus, Michael; Bax, Jeroen J.; Prasad, Abhiram; Di Mario, Carlo; Böhm, Michael; Gasparini, Mauro; Ruschitzka, Frank; Bossone, Eduardo; Citro, Rodolfo; Rinaldi, Mauro; De Ferrari, Gaetano Maria; Lüscher, Thomas; Ghadri, Jelena R.; Templin, Christian;
• Is Part Of: European journal of heart failure. Volume 22:Number 2(2020)
• Page Start: 330
• Page End: 337
• Publication Date: 2019-12-20
• Subjects: Takotsubo syndrome -- Acute heart failure -- Outcome -- Medical therapy -- Aspirin; Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1002/ejhf.1698
• Languages: English
• ISSNs: 1388-9842

Abstract

Abstract: Aims: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS). Methods and results: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30‐day and 5‐year follow‐up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30‐day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50–3.04, P = 0.64] or 5‐year follow‐up (HR 1.11, 95% CI 0.78–1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS‐based methods, i.e. covariate adjustment and inverse probability of treatment weighting. Conclusion: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30‐day and 5‐year follow‐up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.