Imaging to study solid tumour origin and progression: lessons from research and clinical oncology. Issue 6 (4th April 2017)

• Record Type: Journal Article
• Authors: Raimondo, Stefania; Zito, Giovanni
• Is Part Of: Immunology and cell biology. Volume 95:Issue 6(2017)
• Page Start: 531
• Page End: 537
• Publication Date: 2017-04-04
• Subjects: Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1038/icb.2017.17
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract : Biomedical imaging in recent decades has clarified our understanding of normal and pathological cellular processes in vivo . In particular, this approach recently provided insights into processes occurring at a molecular or genetic level rather than at the anatomical level. The evolution of this discipline by engineering have led to its integration into biomedical research to (1) increase sensitivity and resolution imaging and to (2) improve tissue and cell specificity. Currently, imaging approaches are used in three different biomedical areas: (a) identification of cellular processes in physiological and disease state; (b) in vivo single‐cell imaging; and (c) identification of new prognostic and therapeutical strategies. In this review, we will focus on the state of art of biomedical imaging in cancer. Specifically, we will highlight the most important advances in imaging tools available for basic and translational cancer research, with a particular emphasis on solid tissue malignancies. Abstract : Since microscopes were first invented, scientists have constantly been drawn to these marvellous machines. This is because microscopes provide their user with the ability to view first hand minuscule objects and processes they have often dedicated their entire careers to studying. It is this ability to view biology at work in both space and time, from a single molecule to an entire organism that makes imaging such a powerful tool. In this Special Feature, we have compiled a series of articles that discuss the history of microscopes and imaging modalities. We look at how current platforms have influenced basic research of immunology and cell biology as well as their use in the clinic to diagnose and treat disease. We also discuss how future developments in technology will open avenues for an even deeper understanding of fundamental principles in biology and the challenges associated with handling vast amounts of data generated by technology that gives such a high level of deta iled information. Immunology & Cell Biology thanks the coordinator of this Special Feature ‐ Edwin Hawkins ‐ for his planning and input.