Cover Picture: Assessment of a Large Enzyme–Drug Complex by Proton‐Detected Solid‐State NMR Spectroscopy without Deuteration (Angew. Chem. Int. Ed. 17/2019). Issue 17 (5th March 2019)

• Record Type: Journal Article
• Authors: Vasa, Suresh K.; Singh, Himanshu; Grohe, Kristof; Linser, Rasmus
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 17(2019)
• Page Start: 5465
• Page End: 5465
• Publication Date: 2019-03-05
• Subjects: protein function -- protein structure -- proton detection -- solid-state NMR spectroscopy -- ultrafast MAS; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201902502
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Moving pictures of proteins were obtained by solid‐state NMR spectroscopy of small amounts of non‐deuterated sample by employing fast magic‐angle‐spinning rotors. From a consideration of previous approaches involving deuteration, this preview by R. Linser and co‐workers forecasts a largely facilitated sample preparation even for demanding future targets. In their Communication on page 5758 ff., they describe comprehensive insight into the structure and dynamics of a complex between a 29 kDa enzyme and a small‐molecule inhibitor.