Stereospecific Al‐Catalysed Tandem C−N/C−Se Bond Formation of Isoselenocyanates with Aziridines: Synthesis and DFT Study. Issue 1 (19th November 2018)

• Record Type: Journal Article
• Authors: Satheesh, Vanaparthi; Srivastava, Hemant Kumar; Kumar, Sundaravel Vivek; Sengoden, Mani; Punniyamurthy, Tharmalingam
• Is Part Of: Advanced synthesis & catalysis. Volume 361:Issue 1(2019)
• Page Start: 55
• Page End: 58
• Publication Date: 2018-11-19
• Subjects: stereospecific -- C−Se bond formation -- Al-catalysis -- computational study -- heterocycle; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201801116
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: Al‐catalyzed stereospecific tandem C−N / C−Se bond formation of chiral aziridines with isoselenocyanates is described with 90–99% ee and 77–91% yields. The mechanistic investigation using the computational study suggests that the reaction involves a concerted pathway (SN 2). The selectivity and substrate scope are the important practical features. Abstract :