NHC‐Stabilized Iridium Nanoparticles as Catalysts in Hydrogen Isotope Exchange Reactions of Anilines. Issue 9 (29th January 2020)

• Record Type: Journal Article
• Authors: Valero, Mégane; Bouzouita, Donia; Palazzolo, Alberto; Atzrodt, Jens; Dugave, Christophe; Tricard, Simon; Feuillastre, Sophie; Pieters, Grégory; Chaudret, Bruno; Derdau, Volker
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 9(2020)
• Page Start: 3517
• Page End: 3522
• Publication Date: 2020-01-29
• Subjects: C−H activation -- C−H functionalization -- heterogeneous catalysis -- hydrogen isotope exchange -- iridium nanoparticles; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201914369
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The preparation of N‐heterocyclic carbene‐stabilized iridium nanoparticles and their application in hydrogen isotope exchange reactions is reported. These air‐stable and easy‐to‐handle iridium nanoparticles showed a unique catalytic activity, allowing selective and efficient hydrogen isotope incorporation on anilines using D2 or T2 as isotopic source. The usefulness of this transformation has been demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals. Abstract : Iridium nanoparticles stabilized by N‐heterocyclic carbenes were prepared and applied in hydrogen isotope exchange reactions. These air‐stable and easy‐to‐handle nanoparticles allowed selective and efficient hydrogen isotope incorporation on anilines using D2 or T2 as isotopic source. Their usefulness was demonstrated by the deuterium and tritium labeling of diverse complex pharmaceuticals.