A Fatal Case of Poisoning with Fentanyl Transdermal Patches in Japan. Issue 6 (24th July 2019)
- Record Type:
- Journal Article
- Title:
- A Fatal Case of Poisoning with Fentanyl Transdermal Patches in Japan. Issue 6 (24th July 2019)
- Main Title:
- A Fatal Case of Poisoning with Fentanyl Transdermal Patches in Japan
- Authors:
- Nara, Akina
Yamada, Chiho
Saka, Kanju
Kodama, Takanori
Yoshida, Masaki
Iwahara, Kaori
Takagi, Tetsuya - Abstract:
- Abstract: Fentanyl transdermal patches have been used to treat cancer‐ and noncancer‐related chronic pain. However, its inappropriate or illegal application may cause fatal poisoning. We herein present the case of a Japanese woman in her 40s who was found dead with seven 25‐μg/h fentanyl transdermal patches on her body. We established a detailed toxicological analysis procedure to quantify fentanyl, and its metabolite norfentanyl, and other drugs (acetaminophen, allylisopropylacetylurea, celecoxib, estazolam, promethazine, and sertraline) in human whole blood by ultra‐high‐performance liquid chromatography–tandem mass spectrometry. The measured fentanyl and norfentanyl concentrations in the femoral and cardiac blood were 0.051 and 0.072 μg/mL and 0.033 and 0.076 μg/mL, respectively. The decedent's fentanyl concentrations were consistent with previously reported postmortem blood levels for fatal cases of poisoning by fentanyl transdermal patches. Based on the decedent's case history, autopsy findings, and toxicological analyses, the cause of death was identified as intoxication with transdermal fentanyl.
- Is Part Of:
- Journal of forensic sciences. Volume 64:Issue 6(2019)
- Journal:
- Journal of forensic sciences
- Issue:
- Volume 64:Issue 6(2019)
- Issue Display:
- Volume 64, Issue 6 (2019)
- Year:
- 2019
- Volume:
- 64
- Issue:
- 6
- Issue Sort Value:
- 2019-0064-0006-0000
- Page Start:
- 1936
- Page End:
- 1942
- Publication Date:
- 2019-07-24
- Subjects:
- forensic science -- forensic toxicology -- fentanyl -- transdermal patch -- whole blood -- QuEChERS -- ultra‐high‐performance liquid chromatography–tandem mass spectrometry
Medical jurisprudence -- Periodicals
Forensic sciences -- Periodicals
Forensic Medicine -- Periodicals
Gerechtelijke geneeskunde
Gerechtelijke chemie
Gerechtelijke psychiatrie
363.2505 - Journal URLs:
- http://catalog.hathitrust.org/api/volumes/oclc/1754597.html ↗
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1556-4029 ↗
http://www.blackwell-synergy.com/loi/jfo ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1111/1556-4029.14127 ↗
- Languages:
- English
- ISSNs:
- 0022-1198
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4984.600000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 17505.xml