Salvage surgery for recurrent larynx cancer. Issue 11 (21st August 2019)

• Record Type: Journal Article
• Authors: Mimica, Ximena; Hanson, Martin; Patel, Snehal G.; McGill, Marlena; McBride, Sean; Lee, Nancy; Dunn, Lara A.; Cracchiolo, Jennifer R.; Shah, Jatin P.; Wong, Richard J.; Ganly, Ian; Cohen, Marc A.
• Is Part Of: Head & neck. Volume 41:Issue 11(2019)
• Page Start: 3906
• Page End: 3915
• Publication Date: 2019-08-21
• Subjects: head and neck neoplasm -- larynx cancer -- prognosis -- salvage laryngectomy -- treatment failure; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25925
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Despite advances in treatment, the recurrence rates for laryngeal cancer range from 16% to 40%. Methods: Patients with recurrent laryngeal cancer treated at Memorial Sloan Kettering (MSK) from 1999 to 2016 were reviewed. Survival outcomes were analyzed. Results: Of 241 patients, 88% were male; the median age was 67 years; 71% had primary glottic tumors. At initial treatment, 72% of patients were seen with early stage disease; primary treatment was radiation (68%), chemoradiation (29%), and surgery (3%). The most common salvage surgery was total laryngectomy (74%). Forty‐seven percentage were upstaged at salvage surgery. The 2‐ and 5‐year disease‐specific survival (DSS) was 74% and 57%, respectively. Patients with cT4 disease treated with nonsurgical primary management had a 0% 5‐year DSS. Independent predictors of DSS were tumor location, perineural invasion, margin, and stage. Conclusions: Salvage surgery results in acceptable oncologic outcomes. Stage, disease site, perineural invasion, and margins are associated with inferior DSS.