A Prospective Life Cycle Assessment (LCA) of Monomer Synthesis: Comparison of Biocatalytic and Oxidative Chemistry. Issue 7 (27th February 2019)

• Record Type: Journal Article
• Authors: Delgove, Marie A. F.; Laurent, Achille‐B.; Woodley, John M.; De Wildeman, Stefaan M. A.; Bernaerts, Katrien V.; van der Meer, Yvonne
• Is Part Of: ChemSusChem. Volume 12:Issue 7(2019)
• Page Start: 1349
• Page End: 1360
• Publication Date: 2019-02-27
• Subjects: biocatalysis -- life cycle assessment -- oxidative chemistry -- process metrics -- sustainable chemistry; Green chemistry -- Periodicals; Sustainable engineering -- Periodicals; Chemistry -- Periodicals; Chemical engineering -- Periodicals; 660
• DOI: 10.1002/cssc.201900007
• Languages: English
• ISSNs: 1864-5631

Abstract

Abstract: Biotechnological processes are typically perceived to be greener than chemical processes. A life cycle assessment (LCA) was performed to compare the chemical and biochemical synthesis of lactones obtained by Baeyer–Villiger oxidation. The LCA is prospective (based on experiments at a small scale with primary data) because the process is at an early stage. The results show that the synthesis route has no significant effect on the climate change impact [(1.65±0.59) kg CO 2 gproduct −1 vs. (1.64±0.67) kg CO 2 gproduct −1 ]. Key process performance metrics affecting the environmental impact were evaluated by performing a sensitivity analysis. Recycling of solvents and enzyme were shown to provide an advantage to the enzymatic synthesis. Additionally, the climate change impact was decreased by 71 % if renewable electricity was used. The study shows that comparative LCAs can be used to usefully support decisions at an early stage of process development. Abstract : Finding the greenest route : This early stage life cycle assessment (LCA) compares the environmental impact of biocatalytic and oxidative chemistry. This study shows that comparative LCAs based on laboratory‐scale experiments can be used to target key process performance metrics for process intensification.