Abstract : Nonsymmetrical ligands are usually not considered building blocks for discrete self‐assembled products. In their Communication on page 18424, J. Yuasa and D. Ogata employ a new imidazole/pyridine‐based ditopic ligand as a building block for a dynamic Pd2 L4 open cage compound that is available for turn‐on/off anion binding through stoichiometry‐driven structural transitions.