Tumor‐associated macrophages promote bladder tumor growth through PI3K/AKT signal induced by collagen. Issue 7 (19th June 2019)

• Record Type: Journal Article
• Authors: Qiu, Shi; Deng, Linghui; Liao, Xinyang; Nie, Ling; Qi, Fang; Jin, Kun; Tu, Xiang; Zheng, Xiaonan; Li, Jiakun; Liu, Liangren; Liu, Zhenhua; Bao, Yige; Ai, Jianzhong; Lin, Tianhai; Yang, Lu; Wei, Qiang
• Is Part Of: Cancer science. Volume 110:Issue 7(2019)
• Page Start: 2110
• Page End: 2118
• Publication Date: 2019-06-19
• Subjects: bladder cancer -- collagen -- integrin α2β1 -- PI3K/AKT -- tumor‐associated macrophages; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.14078
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract: The tumor microenvironment is associated with various tumor progressions, including cancer metastasis, immunosuppression, and tumor sustained growth. Tumor‐associated macrophages (TAMs) are considered an indispensable component of the tumor microenvironment, participating in the progression of tumor microenvironment remodeling and creating various compounds to regulate tumor activities. This study aims to observe enriched TAMs in tumor tissues during bladder cancer development, which markedly facilitated the proliferation of bladder cancer cells and promoted tumor growth in vivo. We determined that TAMs regulate tumor sustained growth by secreting type I collagen, which can activate the prosurvival integrin α2β1/PI3K/AKT signaling pathway. Furthermore, traditional chemotherapeutic drugs combined with integrin α2β1 inhibitor showed intensive anticancer effects, revealing an innovative approach in clinical bladder cancer treatment. Abstract : We determined that tumor‐associated macrophages regulate tumor sustained growth by secreting type I collagen, which can activate the prosurvival integrin/PI3K/AKT signaling pathway. Furthermore, traditional chemotherapeutic drugs combined with integrin inhibitor showed intensive anticancer effects, revealing an innovative approach to clinical bladder cancer treatment.