ESIPT‐Based Dual Chemosensor for Sequential Detection of Cd2+/Zn2+ and Nucleoside Triphosphates in Water: Application in Logic Gates. Issue 27 (18th July 2018)

• Record Type: Journal Article
• Authors: Singh, Harminder; Sharma, Rashmi; Bhargava, Gaurav; Kumar, Subodh; Singh, Prabhpreet
• Is Part Of: ChemistrySelect. Volume 3:Issue 27(2018)
• Page Start: 7840
• Page End: 7848
• Publication Date: 2018-07-18
• Subjects: Dual sensor -- Ensemble -- Fluorescence -- Nucleoside triphosphates -- Zn2+/Cd2+; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201801196
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Here in, novel excited state intramolecular charge transfer (ESIPT)‐modulated fluorophore based on diphenylpyrimidinone DPHQ has been designed and synthesized. DPHQ shows selective 8‐ fold 'turn‐on' fluorescence response with Cd 2+ /Zn 2+ in buffer (containing 1% CH3 CN, pH 7.2) with low detection limits of 55.7/2.7 nM accompanied with a fluorescent colour change from colourless to cyan. DPHQ–Cd 2+ ensemble undergo selective fluorescence quenching with nucleoside triphosphates but it is silent to nucleoside di‐and mono‐phosphates. It can detect 58.4 nM concentration of adenosine triphosphate (ATP). The binding mode and sensing mechanism of DPHQ with Cd 2+ /Zn 2+ was supported by the change in optical behaviors, density functional theory (DFT) calculations and Job's plot. DPHQ was successfully used for construction of 'Set‐Reset' memorized logic devices and OR, INHIBIT logic gates. As practical applications of DPHQ, we utilized DPHQ for detection of Cd 2+ /Zn 2+ in blood serum and quantification of Zn 2+ in tap water samples. Abstract : Diphenyl pyrimidinone – hydroxyquinoline based fluorophore DPHQ shows 'turn‐on' recognition of Cd 2+ and Zn 2+ in water with detection limit as low as 55.7 and 2.7 nM, in biofluid and its complex DPHQ‐Cd 2+ is used as ensemble for recognition of nucleoside triphosphates with detection limit as low as 58.4 nM in water. The multiple response of DPHQ was explored for fabrication of logic gates.