Multi‐institutional analysis of outcomes following transoral surgery for HPV‐positive oropharyngeal squamous cell carcinoma in elderly patients. Issue 11 (28th August 2019)

• Record Type: Journal Article
• Authors: Jackson, Ryan S.; Chen, Stephanie; Last, Aisling; Khan, Amish; Kallogjeri, Dorina; Van Abel, Kathryn M.; Moore, Eric J.; Pipkorn, Patrik
• Is Part Of: Head & neck. Volume 41:Issue 11(2019)
• Page Start: 3933
• Page End: 3939
• Publication Date: 2019-08-28
• Subjects: elderly -- head and neck cancer -- human papillomavirus -- oropharyngeal cancer -- transoral surgery; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25946
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The incidence of human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC) is rising, even in elderly patients. The outcomes of transoral surgery (TOS) in this population are not entirely known. Methods: A retrospective review was performed at two institutions from October 2003 to September 2016 on patients 70 years or older with HPV‐related OPSCC treated with TOS. Results: A total of 75 patients were included with a mean age of 74 years (70‐87 years). At a median follow‐up of 35.7 months, 3‐year overall survival was 81.5% and disease‐specific survival was 94.3%. Advanced cT stage (odds ratio, 2.74; 95% confidence interval, 1.13‐6.64) negatively impacted OS. Conjunctive consolidation was performed to create a staging system with patients older than 80 years, severe comorbidity, and cT3‐4 having worse survival. Conclusions: Elderly patients with HPV‐related OPSCC treated with TOS have excellent survival and therefore should not be excluded from such therapy based on age alone.