Duodenal nutrient exposure contributes to enhancing gastric accommodation. Issue 11 (26th August 2019)

• Record Type: Journal Article
• Authors: Carbone, Florencia; Verschueren, Sofie; Rotondo, Alessandra; Tack, Jan
• Is Part Of: Neurogastroenterology & motility. Volume 31:Issue 11(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-08-26
• Subjects: gastric accommodation -- nutrient volume tolerance -- pyloric obstruction; Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.13697
• Languages: English
• ISSNs: 1350-1925

Abstract

Abstract: Background: The gastric accommodation reflex consists of a relaxation which creates a reservoir for the ingested food before emptying to the duodenum occurs. The mechanisms that control gastric accommodation are not fully understood. This study aims to use intragastric pressure (IGP) measurement and pyloric balloon obstruction to determine the contribution of duodenal nutrient exposure to gastric accommodation and meal‐induced satiation. Methods: Two conditions were tested in 11 healthy subjects (28.3 ± 3.2 years; 23.6 ± 0.7 kg/m 2 ; four females). IGP was measured during an intragastric nutrient drink (ND) infusion at a constant rate (60 mL/min) in the presence of a deflated (control) or inflated (pyloric obstruction) balloon placed into the pylorus. During the study, subjects filled out Likert scales for satiation scores and visual analogue scale for 9 epigastric symptoms (hunger, expected amount to eat, satiation, bloating, fullness, nausea, belching, gastric cramps, and pain) before and during ND infusion until maximal satiation. Key Results: During pyloric obstruction, the IGP drop and the area above the IGP curve (AAC) were significantly smaller compared with the control condition (6.7 ± 1.0 mm Hg vs3.6 ± 0.8 mm Hg, P = .03 and 69.7 ± 13.5 mm Hg × min vs 20.1 ± 9.0 mm Hg × min, P = .001, respectively). Pyloric obstruction decreased nutrient tolerance compared with the control condition (787.9 ± 73.1 mL vs 970.9 ± 79.2 mL, respectively, P < .05). Pyloric obstruction increased symptoms of bloating (1.3 ± 0.4 vs 2.6 ± 0.6; P = .04), fullness (2.3 ± 0.5 vs 3.6 ± 0.3; P = .03), and nausea (0.4 ± 0.2 vs 1.3 ± 0.4; P = .04) compared to control. Conclusion & Inferences: Duodenal nutrient exposure contributes to enhancing gastric accommodation. Preventing the passage of nutrients from the stomach to the duodenum inhibits gastric accommodation and increases meal‐induced satiation, bloating, nausea, and fullness. Abstract : This study supports the role of duodenal feedback on the gastric accommodation reflex. Pyloric obstruction during intragastric infusion of a meal resulted in decreased gastric accommodation and dyspeptic symptoms in healthy subjects.