Morphological changes in the diseased retina on a healthy choroid‐retinal pigment epithelial complex after full macular translocation for exudative age‐related macular degeneration. Issue 2 (3rd October 2018)

• Record Type: Journal Article
• Authors: van Romunde, Saskia Helena Margaretha; Polito, Antonio; Peroglio Deiro, Antonio; Bertazzi, Laura; Guerriero, Massimo; Pertile, Grazia
• Is Part Of: Acta ophthalmologica. Volume 97:Issue 2(2019)
• Page Start: e283
• Page End: e289
• Publication Date: 2018-10-03
• Subjects: age‐related macular degeneration -- choroidal neovascularization -- multimodal imaging -- optical coherence tomography -- submacular surgery; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.13880
• Languages: English
• ISSNs: 1755-375X

Abstract

Abstract: Purpose: To describe the change in the retinal morphology after full macular translocation (FMT) for exudative age‐related macular degeneration (AMD) and identify predictive factors for the visual outcome. Methods: All patients who underwent FMT from December 2008 through July 2013 were selected. Exclusion criteria were FMT for other disease than AMD, age <60 years, <12 months of follow‐up or no available images. Spectral domain optical coherence tomography, fundus autofluorescence, fluorangiography and indocyanine green angiography were evaluated. Results: In total, 51 patients were included with a mean follow‐up of 30 months. The presence of the external limiting membrane (ELM) was a significant predictor for a favourable visual outcome 1 year after FMT (OR = −0.30). Other significant predictive factors were the absence of intraretinal fluid (OR = 0.28) and the mixed choroidal neovascularization type (OR = −0.47), whereas nonresponders (OR = 0.41) and fibrotic lesions (OR = 0.35) were less likely to have a good visual function after surgery. Conclusion: Full macular translocation (FMT), that permits to relocate the diseased macula onto an area of unaffected retinal pigment epithelial and choroid, can restore the anatomy and visual function in some patients with AMD when the outer retina layers are not irreversibly damaged. The presence of the ELM seems to be the most reliable factor in predicting the functional outcome.