SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response. Issue 52 (27th November 2019)

• Record Type: Journal Article
• Authors: Zhuang, Manjiao; Du, Dan; Pu, Lingling; Song, Haixing; Deng, Mian; Long, Qian; Yin, Xiaofei; Wang, Yayu; Rao, Lei
• Is Part Of: Small. Volume 15:Issue 52(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-27
• Subjects: BAY55‐9837 -- exosomes -- SPIONs -- target -- type II diabetes; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201903135
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: BAY55‐9837, a potential therapeutic peptide in the treatment of type 2 diabetes mellitus (T2DM), is capable of inducing glucose (GLC)‐dependent insulin secretion. However, the therapeutic benefit of BAY55‐9837 is limited by its short half‐life, lack of targeting ability, and poor blood GLC response. How to improve the blood GLC response of BAY55‐9837 is an existing problem that needs to be solved. In this study, a method for preparing BAY55‐9837‐loaded exosomes coupled with superparamagnetic iron oxide nanoparticle (SPIONs) with pancreas islet targeting activity and an enhanced blood GLC response with the help of an external magnetic force (MF) is demonstrated. The plasma half‐life of BAY55‐9837 loaded in exosome‐SPION is 27‐fold longer than that of BAY55‐9837. The active targeting property of SIPONs enables BAY‐exosomes to gain a favorable targeting property, which improves the BAY55‐9837 blood GLC response capacity with the help of an external MF. In vivo studies show that BAY‐loaded exosome‐based vehicle delivery enhances pancreas islet targeting under an external MF and markedly increases insulin secretion, thereby leading to the alleviation of hyperglycemia. The chronic administration of BAY‐exosome‐SPION/MF significantly improves glycosylated hemoglobin and lipid profiles. BAY‐exosome‐SPION/MF maybe a promising candidate for a peptide drug carrier for T2DM with a better blood GLC response. Abstract : A nano‐delivery system (BAY‐exosome‐SPION (superparamagnetic iron oxide nanoparticle)) with enhanced blood glucose response capacity is constructed. Exosomes provide BAY55‐9837 with longer plasma half‐life and SIPON enables BAY‐exosome to gain a favorable targeting property. With the help of magnetic force, BAY‐exosome‐SPION can respond properly to the increase of blood glucose, thus accumulates in the pancreas islet and promotes the insulin secretion.