Late pancreatic panniculitis in a simultaneous pancreas kidney transplant patient with failed allografts. Issue 10 (1st July 2019)

• Record Type: Journal Article
• Authors: Baig, Mirza M.; Yaqub, Muhammad S.; Taber, Tim E.; Fridell, Jonathan; Sharfuddin, Asif
• Is Part Of: American journal of transplantation. Volume 19:Issue 10(2019)
• Page Start: 2934
• Page End: 2938
• Publication Date: 2019-07-01
• Subjects: acute -- clinical research/ practice -- complication -- diabetes -- immunosuppression/immune modulation -- immunosuppressive regimens – maintenance -- insulin/C‐peptide -- medical/metabolic -- pancreas/simultaneous pancreas‐kidney transplantation -- pathology/histopathology -- rejection -- type 1; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.15485
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : We present a rare case of pancreatic panniculitis in a 59‐year‐old male simultaneous pancreas–kidney (SPK) recipient with failed allografts. The patient presented with fever and painful erythematous nodules on his leg 1 month after stopping all immunosuppression. A thorough infectious and rheumatological workup was negative. He had pancreas rejection 4 years after SKP transplant and was restarted on dialysis after 14 years when his renal allograft failed due to chronic allograft nephropathy. His chronic immunosuppression (tacrolimus, azathioprine) was stopped and prednisone was weaned over 3 months at that time. A skin biopsy revealed saponification of the subcutaneous fat with inflammation pathognomonic of pancreatic panniculitis. Concurrent allograft pancreatitis confirmed with elevated lipase and a computed tomography scan finding of peripancreatic graft stranding and atrophic native pancreas. He was started on pulse steroid therapy for 3 days followed by oral taper. This resulted in dramatic resolution of all skin lesions and normalization of lipase levels within 1 week, followed by resumption of low‐dose tacrolimus and azathioprine. This is an extremely rare occurrence of panniculitis in pancreas allograft after 10 years of pancreatic failure associated with stopping immunosuppression. Abstract : The authors present a case report of a rare dermatological manifestation of pancreatic rejection associated with cessation of immunosuppression leading to pancreatic panniculitis, which was successfully reversed with resumption of immunosuppression.