Patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers: Implications for postoperative radiotherapy target volumes. Issue 11 (20th August 2019)

• Record Type: Journal Article
• Authors: Cho, Yeona; Yoon, Hong In; Lee, Ik Jae; Kim, Jun Won; Lee, Chang Geol; Choi, Eun Chang; Kim, Se‐Heon; Keum, Ki Chang
• Is Part Of: Head & neck. Volume 41:Issue 11(2019)
• Page Start: 3916
• Page End: 3923
• Publication Date: 2019-08-20
• Subjects: oral cancer -- oropharyngeal cancer -- reconstruction -- recurrence -- surgery; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.25928
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: We aimed to determine the patterns of local recurrence after curative resection and reconstruction for oropharyngeal and oral cancers. Methods: One hundred‐fourteen patients with oropharyngeal and oral cancers underwent resection and reconstruction. The local recurrences were classified as "intra‐flap" (the recurrent tumor was located in the flap tissue), "marginal" (≤5 mm from the flap anastomosis), and "outside" (in the original tissue and >5 mm from the anastomosis) recurrences. Results: Twenty‐seven patients (23.7%) experienced local recurrence, while 32 (28.1%) experienced regional, and nine (7.9%) recurred distantly. Among those who showed local recurrence, one developed "outside" recurrence and the remaining 26 developed "marginal" recurrences. Age >60 years and lymph node metastasis were associated with poor disease‐free survival and overall survival (OS), while the perineural invasion was related to poor locoregional failure‐free survival and OS. Conclusion: Most recurrences developed at the anastomosis marginal site, while none developed in the flap tissue.