Concordance of hospitalizations between Clinical Practice Research Datalink and linked Hospital Episode Statistics among patients treated with oral antidiabetic therapies. Issue 10 (22nd July 2019)

• Record Type: Journal Article
• Authors: Saine, M. Elle; Carbonari, Dena M.; Newcomb, Craig W.; Gallagher, Arlene M.; Blak, Betina T.; Roy, Jason A.; Wood, Jennifer; Cardillo, Serena; Hennessy, Sean; Strom, Brian L.; Lo Re, Vincent
• Is Part Of: Pharmacoepidemiology and drug safety. Volume 28:Issue 10(2019)
• Page Start: 1328
• Page End: 1335
• Publication Date: 2019-07-22
• Subjects: CPRD -- Clinical Practice Research Datalink -- HES -- Hospital Episode Statistics -- hospitalization -- linkage; Pharmacoepidemiology -- Periodicals; Chemotherapy -- Periodicals; Epidemiology -- Periodicals; 615.705
• DOI: 10.1002/pds.4853
• Languages: English
• ISSNs: 1053-8569

Abstract

Abstract: Purpose: The ability of the Clinical Practice Research Datalink (CPRD) to ascertain all‐cause hospitalizations remains unknown. We determined the proportion of hospitalizations in CPRD that were also recorded in Hospital Episode Statistics (HES), and vice versa, among patients initiating oral antidiabetic (OAD) therapy. Methods: We conducted a retrospective cohort study from October 2009 to September 2012 among OAD‐treated patients registered with general practitioners who contribute to CPRD and consent to HES linkage. In CPRD, we identified initial hospitalizations for each calendar year by an Inpatient Referral, Consultation Type code, or Read code indicating an inpatient episode and determined if an admission date was recorded in HES within ±30 days. We then identified initial HES admission dates and determined if a hospitalization was documented in CPRD within ±30 days. Sensitivity analyses were conducted utilizing HES discharge, rather than admission, dates. Results: Among 8574 OAD‐treated HES‐linked patients in CPRD, 6574 initial hospitalizations across the study period were identified in CPRD, and 5188 (78.9% [95% CI, 77.9%‐79.9%]) were confirmed by a HES admission date within ±30 days (median difference, ±3 days [IQR, 1‐7 days]). Among 8609 initial hospital admissions in HES, 4803 (55.7% [95% CI, 54.7%‐56.8%]) hospitalizations were recorded in CPRD within ±30 days (median difference, ±4 days [IQR, 1‐9 days]). Similar results were observed using HES discharge dates. Conclusion: A substantial minority of patient‐level hospitalization data are nonconcordant between HES and CPRD. Pharmacoepidemiologic studies within CPRD that seek to identify hospitalizations should consider linkage with HES to ensure adequate ascertainment of inpatient events.