Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense. Issue 3 (12th February 2013)

• Record Type: Journal Article
• Authors: Farache, Julia; Zigmond, Ehud; Shakhar, Guy; Jung, Steffen
• Is Part Of: Immunology and cell biology. Volume 91:Issue 3(2013)
• Page Start: 232
• Page End: 239
• Publication Date: 2013-02-12
• Subjects: intestine -- macrophages -- dendritic cells -- homeostasis -- inflammation; Immunology -- Periodicals; Cytology -- Periodicals; 616.079
• DOI: 10.1038/icb.2012.79
• Languages: English
• ISSNs: 0818-9641

Abstract

Abstract : Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria‐resident CD103 + dendritic cells and CX3CR1 + macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD). Abstract : The March 2013 issue of Immunology and Cell Biology contains a special feature that focuses on the role of the intestinal epithelial barrier and innate immune cells, examines their crosstalk with the commensal flora, and assesses their contribution to intestinal immunity in health and disease. There is a complexity of interaction among these distinct components and the Reviews of this special feature examine, unravel and investigate the action and reaction in the intestinal homeostasis‐perturbation cycle. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Nature Publishing Group.