Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force. (9th September 2018)

• Record Type: Journal Article
• Authors: Parmar, Malin; Torper, Olof; Drouin‐Ouellet, Janelle
• Is Part Of: European journal of neuroscience. Volume 49:Number 4(2019)
• Page Start: 463
• Page End: 471
• Publication Date: 2018-09-09
• Subjects: cell reprogramming -- human embryonic stem cells -- human‐induced pluripotent stem cells -- induced neurons -- Parkinson's disease -- Star Wars -- transplantation; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.14109
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: This review describes the history, development, and evolution of cell‐based replacement therapy for Parkinson's disease (PD), from the first pioneering trials with fetal ventral midbrain progenitors to future trials using stem cells as well as reprogrammed cells. In the spirit of Tom Isaacs, the review takes parallels to the storyline of Star Wars, including the temptations from the dark side and the continuous fight for the light side of the Force. It is subdivided into headings based on the original movies, spanning from A New Hope to the Last Jedi. Abstract : In this Star Wars themed review written in memory of Tom Issacs, we discuss the ongoing journey that started decades ago to find the right source of cells to achieve brain repair for Parkinson's disease patients by cell therapy.