LINC00311 promotes cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in human papillary thyroid cancer. (2nd January 2020)

• Record Type: Journal Article
• Authors: Gao, Yu; Wang, Fan; Zhang, Li; Kang, Mei; Zhu, Liyang; Xu, Lei; Liang, Wei; Zhang, Wei
• Is Part Of: Cancer medicine. Volume 9:Number 4(2020)
• Page Start: 1515
• Page End: 1528
• Publication Date: 2020-01-02
• Subjects: LINC00311 -- MiR‐330‐5p -- papillary thyroid cancer -- spheroid formation -- stem‐like properties -- TLR4; 616.994005
• DOI: 10.1002/cam4.2815
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Growing evidence has suggested that long noncoding RNAs (lncRNAs) play an essential role in the progression of papillary thyroid cancer (PTC). LncRNA LINC00311 was found to be able to regulate many cellular process in several diseases. However, the function and regulatory mechanism of LINC00311 remains unclear in PTC. In the present study, the results showed that the expression of LINC00311 was upregulated in PTC tissues and cells. Furthermore, knockdown of LINC00311 dramatically suppressed spheroid formation, proliferation, migration, and invasion in PTC cells in vitro. Mechanistic investigations revealed that LINC00311 was negatively correlated with the expression of miR‐330‐5p, meanwhile, TLR4 was a direct target of miR‐330‐5p. In addition, rescue assays further determined that LINC00311 contributed to the progression of PTC through regulating TLR4 expression. Taken together, these findings indicated that LINC00311 could promote cancer stem‐like properties by targeting miR‐330‐5p/TLR4 pathway in PTC. Abstract : The expression of LINC00311 was increased in PTC tissues and cells, and knockdown of LINC00311 suppressed the spheroid formation in PTC cells,