Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis. (8th June 2017)

• Record Type: Journal Article
• Authors: Hirashima, Tsuyoshi; Rens, Elisabeth G.; Merks, Roeland M. H.
• Other Names: INOUE Y. guestEditor.; AKIYAMA M. guestEditor.
• Is Part Of: Development growth and differentiation. Volume 59:Number 5(2017)
• Page Start: 329
• Page End: 339
• Publication Date: 2017-06-08
• Subjects: blood vessel formation -- cellular Potts model -- cystogenesis -- tube morphogenesis; Embryology -- Periodicals; Developmental biology -- Periodicals; Growth -- Periodicals; 574.3
• DOI: 10.1111/dgd.12358
• Languages: English
• ISSNs: 0012-1592

Abstract

Abstract : Mathematical modeling is an essential approach for the understanding of complex multicellular behaviors in tissue morphogenesis. Here, we review the cellular Potts model (CPM; also known as the Glazier‐Graner‐Hogeweg model), an effective computational modeling framework. We discuss its usability for modeling complex developmental phenomena by examining four fundamental examples of tissue morphogenesis: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) blood vessel formation. The review provides an introduction for biologists for starting simulation analysis using the CPM framework. Abstract : We review the cellular Potts model in tissue morphogenesis, and discuss its usability for modeling complex developmental phenomena by examining four fundamental examples: (i) cell sorting, (ii) cyst formation, (iii) tube morphogenesis in kidney development, and (iv) pattern formation in angiogenesis and vasculogenesis.