DNA Vaccine Mediated by Rambutan‐Like Mesoporous Silica Nanoparticles. Issue 1 (24th November 2019)

• Record Type: Journal Article
• Authors: Song, Hao; Yang, Yannan; Tang, Jie; Gu, Zhengying; Wang, Yue; Zhang, Min; Yu, Chengzhong
• Is Part Of: Advanced therapeutics. Volume 3:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-11-24
• Subjects: adjuvant -- DNA vaccine -- gene delivery -- mesoporous silica nanoparticles; Therapeutics -- Periodicals; Pharmaceutical technology -- Periodicals; Pharmacogenetics -- Periodicals; 615.5
• DOI: 10.1002/adtp.201900154
• Languages: English
• ISSNs: 2366-3987

Abstract

Abstract: The development of safe and effective DNA vaccines is of great significance for treating various diseases. Mesoporous silica nanoparticles (MSNs) have been widely employed either for gene delivery or as adjuvants to amplify the immune responses, but rarely reported in DNA vaccines. In this study, the first report of MSNs‐based DNA vaccine by using rambutan‐like MSNs as both gene vector and adjuvant is presented. The high antigen expression and enhanced dendritic cell maturation generated by the MSNs‐based DNA vaccine lead to superior immune response. Boosted antigen‐specific IgG antibody, enhanced cytokine production of IFN‐γ, and amplified CD8 + T cells are observed for mice treated with MSNs‐based vaccines. This study showcases a powerful DNA vaccine platform with outstanding immune responses, which provides useful guidance for the design of effective nanomaterial‐based vaccines. Abstract : A DNA vaccine mediated by rambutan‐like mesoporous silica nanoparticles is presented in this study showing enhanced immune responses in vivo. The nanoparticles act as both gene delivery vectors and immuno‐adjuvants, stimulating the dendritic cells maturation, T cell activation, and antibody production. The work offers a promising DNA vaccine candidate and is expected to provide insights for rational design of effective nanovaccine system.