A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer. (26th December 2019)

• Record Type: Journal Article
• Authors: Yarchoan, Mark; Huang, Chiung‐Yu; Zhu, Qingfeng; Ferguson, Anna K.; Durham, Jennifer N.; Anders, Robert A.; Thompson, Elizabeth D.; Rozich, Noah S.; Thomas, Dwayne L.; Nauroth, Julie M.; Rodriguez, Christina; Osipov, Arsen; De Jesus‐Acosta, Ana; Le, Dung T.; Murphy, Adrian G.; Laheru, Daniel; Donehower, Ross C.; Jaffee, Elizabeth M.; Zheng, Lei; Azad, Nilofer S.
• Is Part Of: Cancer medicine. Volume 9:Number 4(2020)
• Page Start: 1485
• Page End: 1494
• Publication Date: 2019-12-26
• Subjects: checkpoint inhibitor -- colorectal cancer -- immunotherapy -- PD-1 -- vaccine; 616.994005
• DOI: 10.1002/cam4.2763
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Background: Mismatch repair proficient (MMRp) colorectal cancer (CRC) has been refractory to single‐agent programmed cell death protein 1 (PD1) inhibitor therapy. Colon GVAX is an allogeneic, whole‐cell, granulocyte‐macrophage colony‐stimulating factor ‐secreting cellular immunotherapy that induces T‐cell immunity against tumor‐associated antigens and has previously been studied in combination with low‐dose cyclophosphamide (Cy) to inhibit regulatory T cells. Methods: We conducted a single‐arm study of GVAX/Cy in combination with the PD1 inhibitor pembrolizumab in patients with advanced MMRp CRC. Patients received pembrolizumab plus Cy on day 1, GVAX on day 2, of a 21‐day cycle. The primary endpoint was the objective response rate by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Secondary objectives included safety, overall survival, progression‐free survival, changes in carcinoembryonic antigen (CEA) levels, and immune‐related correlates. Results: Seventeen patients were enrolled. There were no objective responses, and the disease control rate was 18% by RECIST 1.1. The median progression‐free survival was 82 days (95% confidence interval [CI], 48‐97 days) and the median overall survival was 213 days (95% CI 179‐441 days). Biochemical responses (≥30% decline in CEA) were observed in 7/17 (41%) of patients. Grade ≥ 3 treatment‐related adverse events were observed in two patients (hemolytic anemia and corneal transplant rejection). Paired pre‐ and on‐treatment biopsy specimens showed increases in programmed death‐ligand 1 expression and tumor necrosis in a subset of patients. Conclusions: GVAX/Cy plus pembrolizumab failed to meet its primary objective in MMRp CRC. Biochemical responses were observed in a subset of patients and have not previously been observed with pembrolizumab monotherapy in MMRp CRC, indicating that GVAX may modulate the antitumor immune response. Abstract : Mismatch repair proficient colorectal cancer has been refractory to single‐agent programmed cell death protein 1 inhibitor therapy. Colon GVAX is an allogeneic, whole‐cell, granulocyte‐macrophage colony‐stimulating factor‐secreting cellular immunotherapy that induces T‐cell immunity against tumor‐associated antigens and has previously been studied in combination with low‐dose cyclophosphamide (Cy) to inhibit regulatory T cells. In this single‐arm study, we find that GVAX/Cy plus pembrolizumab results in biochemical responses but not radiographic responses.