Mathematical model of collective cell migrations based on cell polarity. (17th July 2017)

• Record Type: Journal Article
• Authors: Akiyama, Masakazu; Sushida, Takamichi; Ishida, Sumire; Haga, Hisashi
• Other Names: INOUE Y. guestEditor.; AKIYAMA M. guestEditor.
• Is Part Of: Development growth and differentiation. Volume 59:Number 5(2017)
• Page Start: 471
• Page End: 490
• Publication Date: 2017-07-17
• Subjects: cell migration -- cell polarity -- computer -- mathematical model -- morphogenesis; Embryology -- Periodicals; Developmental biology -- Periodicals; Growth -- Periodicals; 574.3
• DOI: 10.1111/dgd.12381
• Languages: English
• ISSNs: 0012-1592

Abstract

Abstract : Individual cells migrate toward the direction of the cell polarity generated by interior or exterior factors. Under situations without guides such as chemoattractants, they migrate randomly. On the other hand, it has been observed that cell groups lead to systematic collective cell migrations. For example, Dictyostelium discoideum and Madin‐Darby canine kidney (epithelial) cells exhibit typical collective cell migration patterns such as uniformly directional migration and rotational migration. In particular, it has been suggested from experimental investigations that rotational migrations are intimately related to morphogenesis of organs and tissues in several species. Thus, it is conjectured that collective cell migrations are controlled by universal mechanisms of cells. In this paper, we review actual experimental data related to collective cell migrations on dishes and show that our self‐propelled particle model based on the cell polarity can accurately represent actual migration behaviors. Furthermore, we show that collective cell migration modes observed in our model are robust. Abstract : In this paper, we review the actual experimental data related to collective cell migrations on dishes and show that our self‐propelled particle model based on the cell polarity can accurately represent the observed migration behaviors. Furthermore, we show that the collective cell migration modes observed in our model are robust.