Stepping up Th1 immunity to control phagosomal bacteria. Issue 6 (June 2021)

• Record Type: Journal Article
• Authors: Watts, Tania H.
• Is Part Of: Trends in immunology. Volume 42:Issue 6(2021)
• Page Start: 461
• Page End: 463
• Publication Date: 2021-06
• Subjects: T helper cells -- phagosomal pathogens -- IL-12 -- CX3CR1 -- ZEB2 -- cytotoxic CD4 T cells; Immunology -- Periodicals; 571.96
• DOI: 10.1016/j.it.2021.04.008
• Languages: English
• ISSNs: 1471-4906

Abstract

Abstract : How does the immune system tailor effector function to particular threats? Krueger et al. reveal that infection with Salmonella enterica (SE), but not with influenza A virus (IAV), drives interleukin (IL)-12-dependent outgrowth of interferon (IFN)-γ hi type 1 T helper (Th1) cells, leading to superior protection against this phagosomal pathogen. Among these cells are ZEB2-dependent cytotoxic Th1 cells marked by CX3CR1 expression.