Multiple sclerosis: individualized disease susceptibility and therapy response. (February 2013)

• Record Type: Journal Article
• Authors: Pravica, Vera; Markovic, Milos; Cupic, Maja; Savic, Emina; Popadic, Dusan; Drulovic, Jelena; Mostarica-Stojkovic, Marija
• Is Part Of: Biomarkers in medicine. Volume 7:Number 1(2013)
• Page Start: 59
• Page End: 71
• Publication Date: 2013-02
• Subjects: biomarkers -- disease-modifying therapy -- multiple sclerosis -- personalized medicine -- single nucleotide polymorphism; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.12.113
• Languages: English
• ISSNs: 1752-0363

Abstract

Multiple sclerosis (MS) is a heterogeneous disease in which diverse genetic, pathological and clinical backgrounds lead to variable therapy response. Accordingly, MS care should be tailored to address disease traits unique to each person. At the core of personalized management is the emergence of new knowledge, enabling optimized treatment and disease-modifying therapies. This overview analyzes the promise of genetic and nongenetic biomarkers in advancing decision-making algorithms to assist diagnosis or in predicting the disease course and therapy response in any given MS patient.