Clinicopathologic features of anaplastic myxopapillary ependymomas. (1st January 2019)

• Record Type: Journal Article
• Authors: Lee, Julieann C.; Sharifai, Nima; Dahiya, Sonika; Kleinschmidt‐DeMasters, Bette K.; Rosenblum, Marc K.; Reis, Gerald F.; Samuel, David; Siongco, Aleli M.; Santi, Mariarita; Storm, Phillip B.; Ferris, Sean P.; Bollen, Andrew W.; Pekmezci, Melike; Solomon, David A.; Tihan, Tarik; Perry, Arie
• Is Part Of: Brain pathology. Volume 29:Number 2(2019)
• Page Start: 75
• Page End: 84
• Publication Date: 2019-01-01
• Subjects: anaplastic transformation -- CSF dissemination -- malignant neoplasm -- metastasis -- microvascular proliferation -- myxopapillary ependymoma -- necrosis -- recurrence; Nervous system -- Diseases -- Periodicals; Brain -- Diseases -- Periodicals; Neurology -- Periodicals; Brain Diseases -- Periodicals; Cerveau -- Maladies -- Périodiques; Système nerveux -- Maladies -- Périodiques; Neurologie -- Périodiques; 616.805
• DOI: 10.1111/bpa.12673
• Languages: English
• ISSNs: 1015-6305

Abstract

Abstract: Myxopapillary ependymomas (MPE) are considered benign (World Health Organization (WHO) grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. We retrieved 14 anaplastic MPEs from the pathology archives of six institutions. Each tumor included at least two of the following features: ≥5 mitoses per 10 high power fields, Ki‐67 labeling index (LI) ≥10%, microvascular proliferation (MVP) and spontaneous necrosis. These features were typically encountered in the foci of hypercellularity and reduced mucin. There were eight male and six female patients (age range 6–57 years, median = 16.5). Ten tumors displayed anaplasia at initial resection, and 4 were anaplastic at a second surgery for recurrence (ranging from 9 months to 14 years following initial resection). The Ki‐67 LI ranged between 8% and 40% in the anaplastic foci and <3% in the foci of classic MPE. There was documented cerebrospinal fluid (CSF) dissemination in seven cases, recurrence following an anaplastic diagnosis in three cases and bone or soft tissue invasion in two cases. One patient suffered lung metastases. Two cases evaluated by targeted next‐generation sequencing and one evaluated by fluorescence in situ hybridization (FISH) showed nonspecific chromosomal gains. We conclude that although rare, anaplastic MPE occurs in both pediatric and adult patients, similar to other ependymomas. At a minimum, closer follow‐up is recommended, given the concern for aggressive biologic potential. Further study is needed to determine WHO grading criteria and genetic indicators of tumor progression.